RRP $50
1 % HA (Hyaluronic Acid)
High Molecular Weight HA perfect for Professional Use for CIT or electroporation
Why use High Molecular weight Hyaluronic Acid (HMWHA) instead of Low Molecular weight Hyaluronic Acid (LMWHA) during professional treatments, especially post needling?
Following tissue injury, monocytes can enter the tissue and differentiate into fibroblast-like cells called fibrocytes, but little is known about what regulates this differentiation.
The Extracellular matrix contains high molecular weight hyaluronic acid (HMWHA; ∼2×106 Da). During injury, HMWHA breaks down to low molecular weight hyaluronic acid (LMWHA; ∼0.8–8×105 Da).
HMWHA potentiates the differentiation of human monocytes into fibrocytes, while LMWHA inhibits fibrocyte differentiation. Monocytes internalize HMWHA and LMWHA equally well. HMW-HA promotes regenerative healing in adult wounds.
On the other hand, LMW-HA and intermediate-weight HA increase the expression of macrophage inflammatory protein-1a and monocyte chemotactic protein-1, which may suggest that LMW-HA is important in the induction of the inflammatory cascade
